The Effect of Steroid on Intraocular Pressure In Children with Nephrotic Syndrome
Amra, Aryani A
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Nephrotic Syndrome (NS) is defined by the presence of nephrotic range proteinuria, edema hyperlipidemia and hypoalbuminemia. Nephrotic syndrome in children is the most common renal disease in Indonesia. Steroid in NS could lower mortality rate. Long term of steroid has gained notoriety due to its tendency to induce multiple side effects, including higher intraocular pressure (IOP). The aim of this current study to determine ocular abnormalities in children such as higher IOP with NS from prolonged corticosteroid therapy. A serial prospective analytic case study was conducted at the Adam Malik Hospital from march 2015 to august 2015 after approved by The Ethics Committee for Health Research Faculty of Medicine Sumatera Utara University. We analyzed IOP in 20 children with NS. The IOP was assessed before steroid treatment, 1st and 2nd month after steroid treatment. IOP was assessed until 2nd month after steroid treatment. After steroid treatment, from the statistical there is a significant differences correlation between IOP and duration of steroid in children with ns (p=0,031). No significant differences between IOP with age and total dose of steroid (p>0,05). NS in children with longer duration of steroid therapy have greater risk of higher IOP. So, Pediatricians are advised to refer NS patients to Ophthalmologist for evaluation.