Correlation between Verruca Vulgaris and Superoxide Dismutase

Abstract

Background: Verruca vulgaris is a form of benign tumors that infected epidermal cells caused by Human papillomavirus (HPV). In several studies states that imbalances in oxidant and antioxidant systems play an important role in HPV infection. SOD is a potent protective enzyme that selectively cleanses radicals of antioxidants by catalyzing dismutation to hydrogen peroxide. Aim: The study aimed to determine the correlation between SOD level and verruca vulgaris. Methods: This was an analytic study with a cross sectional design involving 35 subjects with verruca vulgaris and 35 healthy controls. Diagnosis of verruca vulgaris was made based on history and clinical examination. The authors conducted blood sampling and measurement of plasma SOD level to the patients and controls. Results: The study found that the mean of SOD levels in verruca vulgaris patients were higher (49.27 ± 100.47 U/L) than controls (35.12 ± 50.44 U/L), but it didn’t find a correlation between verruca vulgaris and SOD with p = 0.511. The mean level of ≥ 6 months were higher (59.69 ± 140.85 U/L) than < 6 months (39.43 ± 36.09 U/L) with p = 0.369. The mean multiple lesion levels were higher (62.12 ± 140.76 U/L) than the SOD level of patients with a single lesion (37.14 ± 34.89 U/L) with p = 0.405. The mean of SOD levels of patients who had previously experienced verruca vulgaris was higher (72.79 ± 151.73 U/L) than those who had not it (31.63 ± 18.26 U/L) with p = 0.961. Conclusion: We didn’t found a correlation between verruca vulgaris and SOD.