Comparison of Ceruloplasmin Serum Level in Early Onset and Late Onset Severe Preeclampsia
Muara Panusunan, Lubis
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This research is supposed to find the difference in ceruloplasmin serum level between patient with early and late onset severe preeclampsia. This is a comparative analytic study with cross sectional design. Study subjects were pregnant women admitted to obstetric ward and emergency room of H. Adam Malik General Hospital and USU Medical Faculty satellite hospitals, who fulfilled the inclusion criteria. 40 subjects were obtained, with 20 cases of early onset severe preeclampsia and 20 cases of late onset severe preeclampsia. From 40 subjects obtained, the average ceruloplasmin serum level was higher in subjects with early onset severe preeclampsia (0,899 g/L) compared to late onset severe preeclampsia (0,663 g/L) with p-value <0.05. From Pearson correlation test, a weak inverted correlation (- 0,668) between gestational age of subjects with early onset severe preeclampsia and ceruloplasmin serum level (p-value 0,001), and a strong inverted correlation (- 0,802) between gestational age of subjects with late onset severe preeclampsia and ceruloplasmin serum level (p-value < 0,05) were found. Average serum level of ceruloplasmin is higher in subjects with early onset severe preeclampsia compared to late onset severe preeclampsia (p-value <0.05). There’s a strong inverted correlation between gestational age, whether in early or late onset severe preeclampsia with ceruloplasmin serum level. With the increase of gestational age, the level of ceruloplasmin will decrease.