• Login
    View Item 
    •   Home
    • Lecture Papers (LP)
    • LP - National Published Articles
    • View Item
    •   Home
    • Lecture Papers (LP)
    • LP - National Published Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Long Term Efficacy in Adalimumab for Rheumatoid Arthritis Therapy

    Thumbnail
    View/Open
    Fulltext (368.7Kb)
    Peer_review (966.5Kb)
    Similarity (1.312Mb)
    Date
    2020
    Author
    Marpaung, Blondina
    Metadata
    Show full item record
    Abstract
    Great advances in the treatment of chronic autoimmune inflammatory arthritis, concerning both therapeutic concepts and means, have marked the last two decades. In the 1990s the inversion of the classical “therapeutic pyramid” for the treatment of rheumatoid arthritis (RA) became mainstream in rheumatologypractice,whilelatertheconcept“treatearlytotreateffectively”wasrealizedasanecessity in order to achieve favorable outcomes in RA both in the short and long term. Concerning medications methotrexate (MTX) was regarded as the “anchor drug” for the treatment of RA,while other disease- modifying anti-rheumatic drugs (DMARDs) such as cyclosporine A and leflunomide were recruited or developed to add further therapeutic benefit against chronic inflammatory arthritis as monotherapy or in combination.1 Despite the implementation of these new therapeutic concepts and agents there were issues still to be addressed. A considerable proportion of patients with RA could experience no significant benefit: for example in randomized controlled trials in early RA, 35% of patients receiving MTX monotherapy failed to achieve a 20% American College of Rheumatology (ACR) response at year 1 and 44% at year 2.
    URI
    http://repository.usu.ac.id/handle/123456789/71402
    Collections
    • LP - National Published Articles [1429]

    University of Sumatera Utara Institutional Repository (USU-IR)
    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of USU-IRCommunities & CollectionsBy Issue DateTitlesAuthorsAdvisorsSubjectsTypesBy Submit DateThis CollectionBy Issue DateTitlesAuthorsAdvisorsSubjectsTypesBy Submit Date

    My Account

    LoginRegister

    University of Sumatera Utara Institutional Repository (USU-IR)
    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV