Alteration of Salivary Calcium and Statherin Levels in Patients with Gingivitis and Periodontitis
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Salivary proteins have an important influence in tooth enamel remineralize associated with calcium hydroxyapatite. Statherin is the most powerful protein that binds calcium hydroxyapatite in saliva than other calcium-binding protein. Infection in gingiva and periodontal caused alteration of statherin and calcium levels. Therefore, researchers wanted to determine and to compare salivary statherin and calcium levels in gingivitis and periodontitic mainly on the Indonesian as an initial data to explore the influence of statherin and calcium in patients with gingivitis and periodontitic. By spitting method, 54 samples of whole saliva taken from gingivitis and periodontitic patients ; aged 20-50 years, doesn’t have antibiotic treatment in 3 months, no smoking, no areca chewing, not pregnant, lactating or menstruating. Statherin level measurement using ELISA method and calcium level by spectrophotometry method. Results showed mean concentration of statherin for gingivitis is 1,79 ug / ml, while periodontitics is 2,73 ug / ml. Mean concentration for calcium in gingivitis saliva is 5,31 mmol/l, and periodontitic is 0,18 mmol/l. The Spearman’s correlation test showed 2 different results from 2 groups of samples. Gingivitis group showed there is no correlation between calsium and statherin in saliva (p>0,01), but periodontitic group showed there is significant correlation between calcium and statherin in saliva (p<0,05). The result showed that, although both are the result of salivary excretion (statherin and calcium), it turns out to different infection, showed different result. These results suggest there is a different mechanism in both infection.