Correlation of TNF-α Expression to Clinical Stadium in Nasopharyngeal Carcinoma (NPC)
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Nasopharyngeal Carcinoma (NPC) is one of the most common malignancies in Indonesia with over 13,000 new cases reported yearly, especially in males. TNF-α serum is reported as a new biomarker to predict bone invasion, post-therapy distant metastasis and poor life sustainability in NPC. To identify the expression of TNF-α in regard to clinical stage of NPC. This is an analytic study with 126 NPC samples of patients in Haji Adam Malik General Hospital. NPC was mostly found in the age group 41–60 years (57.1%), males (71.4%), non-keratinising SCC (79.4%), and stage IV group (54.8%). In immunohistochemistry evaluation, most TNF-α is overexpressed in non-keratinising SCC (68.0%), T3-T4 (50.8%), N2-N3 (62.7%) and clinical stage III–IV (69.9%). Spearman’s test for categorical correlation yields a p value of <0,001. Conclusion: There is a significant correlation between TNF-α expression and the stage of NPC.