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dc.contributor.authorYusoff, Nor Adlin
dc.contributor.authorLim, Vuanghao
dc.contributor.authorAl-Hindi, Bassel
dc.contributor.authorRazak, Khairul Niza Abdul
dc.contributor.authorWidyawati, Tri
dc.contributor.authorAnggraini, Dwi Rita
dc.contributor.authorAhmad, Mariam
dc.contributor.authorAsmawi, Mohd Zaini
dc.date.accessioned2019-05-28T04:53:16Z
dc.date.available2019-05-28T04:53:16Z
dc.date.issued2017
dc.identifier.otherIndra
dc.identifier.urihttp://repository.usu.ac.id/handle/123456789/70170
dc.descriptionDwi Rita Anggrainiid
dc.description.abstractAbstract: Background: An aqueous extract (AE) of vinegar made from Nypa fruticansWurmb. can improve postprandial glucose levels in normoglycaemic rats. The aim of this study was to evaluate its antihyperglycaemic activity further using in vivo and in vitro approaches. Methods: AE was administered to streptozotocin (STZ)-induced diabetic rats twice daily at three doses (1000, 500, and 250 mg/kg b.w.) for 12 days p.o. Several biochemical analyses and a histological study of the pancreas and liver were performed, accompanied by a cell culture assay. Results: As compared to diabetic control (DC), AE at the doses of 500 and 1000 mg/kg b.w. caused significant reduction (p < 0.05) of blood glucose, total cholesterol and triglycerides levels, with positive improvement of serum insulin levels. Interestingly, immunohistochemical staining of the pancreas suggested no -cell regeneration, despite significant increase in insulin production. AE-treated groups, however, showed overall restoration of the hepatic histoarchitecture of STZ-induced liver damage, suggesting a possible hepatoprotective effect. The pancreatic effect of AE was further studied through RIN-5F cell culture, which revealed a positive stimulatory effect on insulin release at a basal glucose concentration (1.1 mM). Conclusion: Nypa fruticansWurmb. vinegar’s aqueous extract exerts its antihyperglycaemic activity, at least in part, through insulin stimulatory and hepatoprotective effects.id
dc.language.isoenid
dc.subjectAntihyperglycaemicid
dc.subjectHepatoprotectiveid
dc.subjectNypa fruticans Wurmbid
dc.subjectVinegarid
dc.subjectDiabetesid
dc.subjectRIN-5Fid
dc.subjectNatural productid
dc.titleNypa Fruticans Wurmb. Vinegar’s Aqueous Extract Stimulates Insulin Secretion and Exerts Hepatoprotective Effect on STZ-Induced Diabetic Ratsid
dc.typeLecture Papersid


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