Correlation between Superoxide Dismutase Level and Disease Activity of Vitiligo
Jusuf, Nelva Karmila
Putri, Kharina Y
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Background: Vitiligo is a chronic systemic acquired disease that has an unpredictable clinical course, characterized by the appearance of macules and achromic or hypochromic patches on the skin and mucous membranes due to the disappearance of melanocytes in the affected area. Until now, the underlying pathogenesis of vitiligo is still unclear. The role of superoxide dismutase (SOD) in vitiligo is mentioned that it can be a biomarker to determine vitiligo activity and progressivity. Aim: To determine correlation between SOD and vitiligo disease activity score (VIDA) Materials and methods: This study was a cross-sectional analytic study which involved 39 vitiligo patients that were diagnosed by clinical and Wood’s lamp examinations. VIDA score was determined to assess lesion activity, which is categorized in the six-point scale. We conducted blood sampling and measurement of SOD level to the patients by ELISA. Results: We found mean SOD in +4 group was 37.55 ng/ml, +3 group was 25.32 ng/ml, +2 group was 4.67 ng/ml, +1 group was 5.60 ng/ml, and 0 group was 3.88 ng/ml. There was is no difference of SOD level based on VIDA score (p=0.775 r=-0.047). In this study, we found the highest mean SOD level in subjects with vitiligo activity lasting from 6 weeks to 3 months and the lowest level in group with lesion activity stable for 1 year. Conclusion: There was no significant correlation between SOD and VIDA score in vitiligo patients.