HER2 Positivity on Recurrent Intracranial Meningioma: Case Report
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The aim of this study was to determine the relationship between meningioma and HER2. Meningiomas are the most common intracranial primary neoplasm in adults. We report here a 39 year-old female with recurrent meningioma; the patient underwent a craniotomy for tumour removal 1 year ago, and had undergone second craniotomy tumour removal. We performed immunohistochemical staining with HER2, which is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of cancer.