Comparison of Accuracy of Fibrosis Ddegree Classification by Liver Biopsy with Fibrosis 4 (Fib 4) Index in Chronic Hepatitis B & C Patients
Zain, Lukman Hakim
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Non invasive test have been constructed and evaillutl:'d main!'. for binary diagnoses such as signilicant fibrosis. Recently detail fibro.,I' c\assificlition for ~cwral nOll illvasive test such a~ Fib4 index have be,'1i develop but their at:cur.u.:y have not been thoroughly evaluated in compari son lo liver biopsy. The aim of this study was to evaluate the accuracy III the detail fibrosis classillcation av'lilable for lib4 index with liver biopsy iii Chronic Hepatitis Band C patienl~. Met/wds: 111 this cross sectional study, 71 patients confirmed with Hepatitis Band C, underwent liver biopsy in Adam Malik Hospital Medan since Januilry 2011 to September 2013. Laboratory was taken such AST. ALT, platelet and personal data. Fib4 index was computed. We used predictive value, AUROC to assess the accuracy of fib4 index with liver biopsy. Results: The Fib4 index (cut off > 1,45) compared to Metavir to diagnose severe fibrosis had sensitivity 78,8%, specificity 57,9%, PPV 61,9%, NPV 75,9%, LR(+) 1,87 and LR(-) 0,37. Accuracy diagnostic was 67,6%, AUROC 0,683 (95% CI:O,558- 0,809) with p < 0,05 Conclusion: Fib4 index can be used for fibrosis degree classification in chronic Hepatitis Band C patients.