The Effect Of Curcumin Extract Toward Mature Brain Derived Neurotrphic Factor (mBDNF) Expression After Traumatic Brain Injury
Hutagalung, Tommy R.
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Background: Traumatic Brain Injury (TBI) causes disability, death and huge economic losses in various countries of the world. TBI incident varies between 67 –317 per 100.000 population, with 4-7% mortality rate in moderate brain injury, and 50% in severe brain injury. The mature BDNF (mBDNF) pathway system is a potential therapeutic target for neurological disorders in traumatic brain injury. Curcumin extract has a neuromodulatory effect which has a modulation effect on the expression and activation of the mBDNF system in the hippocampus area. Methods: Laboratory experimental study in Faculty of medicine University of Brawijaya which used thirty male Sprague-Dawley rats. Rats were divided into three treatment groups, group A (negative control), group B given traumatic brain injury, group C given traumatic brain injury and Curcumin administration. Rats’s brain tissue was immunohistochemically processed, to observe the number of cells expressing mBDNF in the subgranular zone (SGZ) of the hippocampus dentate gyrus (DG). Data were analyzed with SPSS and ANOVA analysis. Result: In ANOVA analysis, mean expression of mBDNF group C compared to group A and group B were increased significantly (p=0.0001). Curcumin through induction of mBDNF and activation of its intracellular receptor TrkB can produce neural regeneration, reconnection, and dendritic sprouting, and can enhance synaptic efficacy. Conclusion : Curcumin can increase the expression of mBDNF in the subgranular zone of the hippocampus dentate gyrus.