Body Mass Index but not 25(OH)D Serum is Associated with Bone Mineral Density Among Indonesian Women in North Sumatera: A Cross Sectional Study
Sari, Dina Keumala
Tala, Zaimah Zulkarnaini
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Background and Objective: The mechanism of low circulating 25(OH)D serum in obese people may be due to high 25(OH)D level in adipocyte resulting low in circulation or low vitamin D binding protein (DBP). However, obese people have a higher Bone Mineral Density (BMD), which suggests that low 25(OH)D may not associate with other bone health parameters such as calcium, C-terminal telopeptide, bone mineral density and T-score. This study aimed to determine whether there is association between 25(OH)D, (1) With bone health parameter differ by body weight and (2) Body mass index and BMD. Methodology: The study design was a cross-sectional study of 132 women aged 20-50 years in North Sumatera, Indonesia. Results: Serum total 25(OH)D was no different in normal, overweight and obese women subjects (15.2±4.9 ng mLG1). There was 77.3% categorized in deficiency and insufficiency (22.7%). There was no association among bone health parameters (calcium serum, C-terminal telopeptide, T-score) and body weight but there is an association between BMI and BMD (p<0.05). Conclusion: Serum total 25(OH))D lower at all categorize body mass index, which cannot be explained by higher in adipocyte and lower in circulation. Lower 25(OH)D may not reflect at risk skeletal health and higher BMI should be considered as a marker of higher BMD.