Tumour Necrosis Factor-Α, Interleukin-1 and Interleukin-6 Serum Levels and Its Correlation with Pain Severity in Chronic Tension-Type Headache Patients: Analysing Effect of Dexketoprofen Administration
Rambe, Aldy Safruddin
Machfoed, Moh Hasan
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AIM: The purpose of this study is to see the effect of Dexketoprofen on TNF-α, IL-1, and IL-6 serum levels in Chronic Tension-Type Headache (CTTH) patients and its correlation with pain severity. METHOD: The study subjects were recruited consecutively from the study population. Venous blood was taken at baseline to measure serum levels of TNF-α, IL-1, and IL-6 and after ten consecutive days of Dexketoprofen 25 mg once daily. RESULTS: Twenty three subjects participated in this study, 3 male (13.0%) and 20 female (87%). A significant difference between NRS score at baseline and after treatment (4.86 � 1.82 vs. 1.96 � 1.40, p = 0.001) was found. No significant difference found between baseline and after treatment TNF-� (1.48 � 0.65 pg/dl vs. 1.48 � 0.63 pg/dl, p = 0.963), IL-1 (0.16 � 0.80 pg/dl vs. 0.26 � 0.31 pg/dl, p = 0.168) nor IL-6 serum levels (1.06 � 0.83 pg/dl vs. 1.04 � 0.81 pg/dl, p = 0.915). A weak negative (R = -0.266) non significant correlation (p = 0.219) was found between NRS score and TNF-�. A positive weak negative (R = 0.221) non significant correlation (p = 0.311) between NRS score and IL-1. NRS score and IL-6 had a negative very weak (R = -0.019) non significant negative correlation (p = 0.931). CONCLUSIONS: Dexketoprofen decreased pain intensity significantly (p = 0.001), but had no effect on TNF-� IL-1 nor IL-6 serum levels. NRS score had a weak and non significant negative correlation with TNF-�, a weak and non significant positive correlation with IL-1, and a very weak and non significant negative correlation with IL-6 serum levels.