Degree of Neutrophil, Atrophy, and Metaplasia Intestinal Were Associated with Malondialdehyde Level in Gastritis Patients
Abstract
The main pathogenesis of gastritis is inflammation that closely related to free
radicals. Malondialdehyde (MDA) is a free radical biomarker and is found to increase in
gastritis patients. However, these studies are generally performed on experimental animals as
well as MDA examination in gastric mucosa.This study aim was to determine the association
of degrees of gastritis (degree of lymphocyte infiltration, neutrophil activity, atrophy, and
intestinal metaplasia) with plasma MDA level. A cross-sectional study of 80 consecutive
gastritis patients who came to an endoscopic unit of Adam Malik General Hospital in Medan,
Indonesia, from May–September 2017. Assessed for severity of chronic inflammatory,
neutrophil activity, atrophy, and intestinal metaplasia refers to Updated Sydney System.
Plasma MDA levels were examined using an HPLC MDA kit. Univariate analysis, bivariate
(chi-square and Fisher exact test), and multivariate (binary logistic regression test) were
programmed with SPSS version 22. There was no significant association between degree of
lymphocyte infiltration with MDA level. There were significant associations between degree of
neutrophil activity, atrophy, and intestinal metaplasia with MDA level (p=0.039, 0.003, 0.021;
respectively). The moderate+severe degree of neutrophil activity, atrophy, and intestinal
metaplasia were associated with high level of MDA.