Apoptotic effect of gentamicin in cochlea ototoxic rat model (preliminary study)
Haryuna, Tengku Siti Hajar
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This study aimed to show the potency of gentamicin in increasing the apoptotic index in the cochlea lateral wall of ototoxic rat models. Eight Rattus norvegicus were divided into two groups: 1) control and 2) gentamicin administered. The rats were terminated to measure the apoptotic index using TUNEL assay of the fibroblasts of the cochlea lateral walls. Data were analysed by using ANOVA, with p <0.05 used as the cut-off for statistical significance. Administration of gentamicin showed increased apoptotic index which was statistically significant (p <0.05). This study demonstrates that gentamicin is a pro-apoptotic and demonstrates its potency.