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dc.contributor.authorSiregar, Kamal Basri
dc.date.accessioned2018-06-05T06:11:05Z
dc.date.available2018-06-05T06:11:05Z
dc.date.issued2015
dc.identifier.otherIndra
dc.identifier.urihttp://repository.usu.ac.id/handle/123456789/69380
dc.descriptionKamal Basri Siregarid
dc.description.abstractIntroduction: Many research showed the importance of HER2 as the new biomarker for breast cancer while its overexpression was greatly associated with increased histopathological grading of breast cancer. Methods: About 90 biopsy were taken from patients with breast cancer from 1 June 2011-1 June 2014. The biopsy samples were then sent to Pathology for HER2 immunohistochemistry. There are three grades of scoring 0 to +3. Score 0/+ 1 as considered negative and score of +3 as considered an HER2 overexpression. Histopathological grading was determined using Nottingham scoring. Statistical analyzes were done with SPSS 16. Categorical Data were analyzed by chi square with a significance limit of 0:05. Results: Majority of samples had HER2 +1 (55.6%) and histopathological grading mostly found in grade 1 (44,4,2%). Prevalence ratio of HER2/Neu and histopathological grading of breast cancer was 7.667. Discussion: HER-2 positive are often associated with poor differentiation, metastasis to the lymph nodes, recurrence, and a high mortality rate. In this study, it was shown that ovcerexpression of HER2 increase 8 times risk of having high histopathological grade. These study results have contributed the means of overexpression HER2/neu to being a factor predictive and prognostic factors as well as a breast cancer therapy. Conclusion: Overexpression of HER2/Neu showed 8 times more likely to have a higher grading breast cancer.id
dc.language.isoenid
dc.subjectHER2 Overexpressionid
dc.subjectBreast Cancerid
dc.subjectHistopathological Gradingid
dc.subjectPromising Prognosticid
dc.subjectPredictive Biomarkerid
dc.titleHER2 Overexpression in Relation to Breast Cancer Histopathological Grading: A Promising Prognostic and Predictive Biomarker for Breast Cancerid
dc.typeLecture Papersid


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