Characterization Simplisia and Ethanolic Extract of Pirdot (Saurauia Vulcani, Korth) Leaves and Study of Antidiabetic Effect in Alloxan Induced Diabetic Mice
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Abstract: Pirdot (Saurauia vulcani, Korth) is a species of Actinidiaceae, has been used to treat diabetes mellitus traditionally and empirically gives satisfactory results. The purpose of this study are to study antidiabetic effect of ethanolic extract of Saurauia vulcani Korth leaves. Saurauia vulcani Korth leaves. This Research also testing antidiabetic activity of Saurauia vulcani Korth leaves ethanolic extract, performed antidiabetic effect on white male mice with alloxan induction method The results simplisia characterization and ethanol extracts obtained water content of 6.65% and 7.25% respectively; water soluble extract was 23.55% and 64.25% respectively. Levels of ethanol soluble extract was 20.32% and 66.45% respectively. Total ash content was 4.01% and 0.60% respectively. Acid insoluble ash content was 0.88% and 0.48% respectively. Phytochemical screening of simplisia and ethanol extract are the same, both showed the presence of flavonoid, glycosides, saponins, tannins and steroids / triterpenoids,. Ethanolic extract of Saurauia vulcani Korth leaves shows good results as antidiabetic effect, indicated by significant depletion of blood glucose level in alloxan induced diabetic mice for ten days. Blood glucose level reduce 55.11%, with ethanolic extract of Saurauia vulcani Korth leaves 200 mg / kg body weight, compare with metformin 50 mg / kg body weight only show blood glucose level reduce 47.76%. Based on the analysis it can be concluded that the ethanolic extract of Saurauia vulcani Korth leaves have an antidiabetic effect.