Modulation Of Antioxidant Status By Curcumin Prevents Cochlear Damage After Noise Exposure
Haryuna, Tengku Siti Hajar
Saragih, Abdul Rachman
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Several studies have discovered that curcumin possesses broad biological/functions, especially amioxidant and antiinflammatory. Noise exposure consequently leads fa increased levels oj radical oxygen species (ROS) production in (he coch/ea, causing cochlear damage alld noise-h1duced hearing loss (NIHL). Treatments that enhance antioxidam defences might protect susceptible individuals from NIHL. This sttldy was conducted to demonstrate curculHin as the safe and effective therapeutic agent in the prevention and treatment of oxidative damage ill jibroblasts within the cochlear supporting tissues and lateral wall following noise exposure by modulating endogenous alllioxidant enzymes, stich as superoxide dismutase (SOD) and catalase (CAT). Twenty-foLlr Ralflls norvegicus were randomly divided illlo 4 groups (I/. = 6). Group I: The cOlllrol group; group 2: noise (+); group 3: lIoise (+), 50 mg!day curculllin (+); group 4: lIoise (+), 100 mg/day curcumill (+). All groups (except group I) were subjected to 100 dB SPL for 2 hours per day for 14 days. Curcumin was admin istered orally for 14 days. All samples were imlllunohistochemistrically examined for the expressions of SOD in cochlear fibroblasts and colorimetrically examinell for CAT levels in cochlear tissues using colorimetric reader. All statistical analyses were performed by Statistical Analysis System (SAS). The resl/lts showed that curcumin is potentially effective in the prevention and treatment of oxidative damage in fibrob lasts within the cochlear supporting tissl/es and lateral wall following noise exposure by modulating the expressions of SOD and CAT levels.