The Increased Expressions of Type IV Collagen in Cochlear Fibroblasts of Diabetic Rat Models Caused by Curcumin Therapy
Haryuna, Tengku Siti Hajar
Taufika, Faathir Agung Ainul
Laksmi, Lidya Imelda
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Damage to fibroblasts within the cochlear lateral wall is suggested as one of the causes of hearing loss in patients with diabetes mellitus. The aim of this study was to prove curcumin as a safe and effective substance to treat the cochlear fibroblasts damage measured by the expressions of type IV collagen. Twenty-four Rattus norvegicus were randomly divided into 6 groups (n=4). Group I: the control group; group II: the diabetic group; group III and IV: the diabetic groups received curcumin therapy 200 and 400 mg/kgBW/day from day 3 - 5; group V and VI: the diabetic groups received curcumin therapy 200 and 400 mg/kgBW/day from day 3 - 10. Curcumin [16.62 ± 0.14]% w/w compared to Standard was administered orally, derived from Curcuma longa Linnaeus (turmeric). All samples were immunohistochemistrically examined for the expressions of type IV collagen in cochlear fibroblasts. Statistically significant differences were found for the expressions of type IV collagen (p<0.05) between group I and II, group II and V, and group II and VI. Curcumin proved to be potentially effective in the treatment of damage to cochlear fibroblasts regarding the increased expression of type IV collagen in diabetic rat models.