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dc.contributor.advisorTanuwijaya, Juanita
dc.contributor.advisorSyafruddin
dc.contributor.authorTanjung, Sri Wahyuni
dc.date.accessioned2016-11-02T07:31:31Z
dc.date.available2016-11-02T07:31:31Z
dc.date.issued2016-11-02
dc.identifier.otherZulhelmi
dc.identifier.urihttp://repository.usu.ac.id/handle/123456789/62431
dc.description091524027en_US
dc.description.abstractMany drugs circulating in the market to reduce or eliminate the pain are called analgesic, one of the drug used were tramadol capsules. Tramadol HCl is a bronsted acid having pKa value of 8.3 was titrated with strong base using solvent mixture of water and ethanol as much as tramadol base soluble in water and ethanol function disolves tramadol base. In the manufacture of pharmaceutical dosage from the drug must accordance with requirements of the fourth edition of the pharmacopoeia Indonesia or other standard of books. The purpose of this study was to determine the levels of tramadol HCl with semi nonaqueos titration method and whether tramadol HCl accordance with the requirements of the fourth edition of the pharmacopoeia Indonesia 1995. The selection of sample is purposive where samples are not choose have the same characteristic with a selected sample, tramadol HCl used samples generic capsules PT Indofarma and PT Kimia Farma as well as branded drugs Tramal® and Tradosik® . This assay using semi nonaqueos titration with solvent mixture of ethanol and water was then added phenolphthalein indicator and titrate with NaOH cause pink discoloration. The results showed levels generic tramadol HCl PT Indofarma (101.68% ± 1.37) , tramadol HCl PT Kimia Farma (103.10% ± 2.49) and branded drugs Tramal® (104.73% ± 2.55) and Tradosik® (106.06% ±1.55), the validity of the test results with the % recovery of tramadol HCl capsule at 100.25% precision test with standard deviation (SD) at 0.72% and relative standard deviation at 0.71%. The assay of tramadol HCl capsule with semi nonaqueos titration can be used and compliance with the requirements of the fourth edition of the pharmacopoeia Indonesia 1995.en_US
dc.description.abstractBanyak obat beredar dipasaran untuk mengurangi atau menghilangkan rasa sakit disebut analgesik, salah satu obat yang digunakan adalah tramadol HCl kapsul.Tramadol HCl merupakan asam bronsted memiliki nilai pKa 8,3 dititrasi dengan basa kuat menggunakan pelarut campuran air dan etanol sama banyak karena tramadol basa sukar larut dalam air dan etanol berfungi melarutkan tramadol basa. Pada pembuatan sediaan farmasi berupa obat harus sesuai dengan persyaratan Farmakope Indonesia atau buku standar lainnya. Penelitian ini bertujuan untuk menentukan apakah kadar tramadol HCl kapsul tersebut dengan menggunakan metode titrasi semi bebas air sesuai persyaratan Farmakope Indonesia edisi IV tahun 1995. Pemilihan sampel secara purposif dimana sampel yang tidak terambil mempunyai karakteristik yang sama dengan sampel yang diteliti, sampel yang dipergunakan tramadol HCl kapsul generik PT Indofarma dan PT Kimia Farma serta obat bermerek Tramal® dan Tradosik®. Penetapan kadar ini menggunakan metode titrasi semi bebas air memakai pelarut campuran etanol dan air menggunakan indikator fenolftalein dan pentiter NaOH 0,05 N menyebabkan perubahan warna merah jambu muda. Penelitian menunjukkan kadar kapsul tramadol HCl generik PT Indofarma (101,68% ± 1,37) dan kapsul tramadol HCl generik PT Kimia Farma (103,10% ± 2,49) serta obat bermerek Tramal® (104,73% ± 2,55) dan Tradosik® (106,06% ± 1,55).Hasil uji validasi dengan % perolehan kembali sebesar 100,25% standar deviasi (SD) 0,72% dan relatif standar deviasi (RSD) sebesar 0,71%. Penetapan kadar tramadol HCl kapsul dengan menggunakan metode titrasi semi bebas air dapat digunakan dan memenuhi persyaratan Farmakope Indonesia Edisi IV tahun 1995.en_US
dc.language.isoiden_US
dc.subjectTramadol HClen_US
dc.subjectSemi Nonaqueos Titrationen_US
dc.titlePenetapan Kadar Tramadol Secara Titrasi Semi Bebas Air Dalam Sediaan Kapsulen_US
dc.typeStudent Papersen_US


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