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dc.contributor.advisorMukhtar, Zulfikri
dc.contributor.authorPurba, Joy Wulansari
dc.date.accessioned2016-04-05T04:38:33Z
dc.date.available2016-04-05T04:38:33Z
dc.date.issued2016-04-05
dc.identifier.otherlili nasution
dc.identifier.urihttp://repository.usu.ac.id/handle/123456789/57854
dc.description117041020en_US
dc.description.abstractProses inflamasi yang terjadi akibat cedera saat Intervensi Koroner Perkutan (IKP) berkaitan dengan progresivitas penyakit jantung koroner dan memiliki hubungan erat dengan proses trombosis. HsCRP sebagai penanda fase akut inflamasi dihubungkan dengan perubahan faktor prokoagulasi dan dapat merubah struktur dan fungsi bekuan fibrin. Fibrin clot strength sebagai gambaran aktivitas trombosit dan fibrinogen telah menjadi faktor risiko baru terhadap kejadian iskemik berulang pasca IKP. Penelitian ini bertujuan untuk mencari hubungan antara High Sensitivity C-Reactive Protein (HsCRP) dengan Fibrin Clot Strength (Kekuatan Bekuan Fibrin) pasca IKP elektif. Studi ini melibatkan 50 pasien dengan angina pektoris stabil yang menjalani IKP elektif di RSUP HAM. Subyek penelitian dibagi menjadi tiga kelompok berdasarkan nilai HsCRP. Parameter proses trombosis ditunjukkan dengan hasil tromboelastografi (TEG). Hasil penelitian menunjukkan kelompok dengan tertile HsCRP tertinggi memiliki nilai fibrin clot strength paling besar (11.39 ± 0.65 vs 8.67 ± 0.59, p = 0.011). HsCRP juga memiliki korelasi yang bermakna dengan TEG-α, TEG-K, TEG-MA, dan TEG-G (p = 0.040, p = 0.012, p = 0.004, p = 0.004). Trombosit merupakan faktor yang mempengaruhi fibrin clot strength dan leukosit yang berhubungan dengan HsCRP. Sebagai kesimpulan, proses trombosis berbanding lurus dengan peningkatan HsCRP yang dibuktikan dengan kenaikan fibrin clot strength. Stratifikasi pasien penting dilakukan mengingat HsCRP dan fibrin clot strength dihubungkan dengan kejadian kardiovaskular mayor pasca IKP. Namun, penelitian lebih lanjut diperlukan untuk membuktikan hal tersebut.en_US
dc.description.abstractImpact of injury during Percutaneous Coronary Intervention (PCI) on inflammation process are associated with progression of coronary disease and also thrombosis process. High Sensitivity C-Reactive Protein (HsCRP), one of the acute phase protein may be linked to procoagulant changes and altered structure and function of the fibrin plaque. Fibrin clot strength represents a function of maximal dynamic properties of fibrin and platelet bonding and becomes novel risk factor for ischemic events after PCI. This study was aimed to find correlation between High Sensitivity C-Reactive Protein (HsCRP) and Fibrin Clot Strength after electif PCI. We included 50 patients with stable angina undergone stenting in Haji Adam Malik General Hospital Medan. Subjects divided into 3 groups based on the value of hsCRP. Thrombosis profile was mentioned by thromboelastogram (TEG). The result of this research exhibit that the highest tertile of hsCRP had significantly higher fibrin clot strength (11.39 ± 0.65 vs 8.67 ± 0.59, p = 0.011). HsCRP also had correlation with TEG-α, TEG-K, TEG-MA, dan TEG-G (p = 0.040, p = 0.012, p = 0.004, p = 0.004). Platelet was associated with the value of fibrin clot strength and leucocyte connected with hsCRP. In conclusion, thrombotic risk associated with elevated hsCRP may be linked to increasement of fibrin clot strength. Patients stratification for inflammation and thrombotic risk is important to prevent major cardiovascular events after PCI. Futher researches needed to investigate the relationship between variablesen_US
dc.language.isoiden_US
dc.titleHubungan High Sensitivity C-Reactive Protein (Hs CRP) dengan Fibrin Clot Strength (Kekuatan Bekuan Fibrin) Pasca Intervensi Koroner Perkutan di Rumah Sakit Umum Haji Adam Maliken_US
dc.typeMaster Thesesen_US


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