Detecting proteinuria: A comparison of diagnostic tests
Ramayani, Oke Rina
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Background Proteinuria is a condition when protein is found in urine, a common symptom in children with renal disorders. Proteinuria can also be found in normal children and in those with non-renal disorders. A high sensitivity test is needed to detect proteinuria. Spectrophotometry has been used as a standard to detect proteinuria, however, it is expensive and not readily available in health clinics. W tested the use of 20% sulfosalicylic acid to detect proteinuria, and compared it to spectrophotometry. The sulfosalicylic acid test is inexpensive, rapid, and easily performed in primary community health centers. Objective To compare 20% sulfosalicylic acid test to spectrophotometry as a diagnostic test for proteinuria. Methods We conducted a cross-sectional study in adam Malik Hospital from September 2009 until December 2009. Inclusion criteria were children aged 3 to 18 years who experienced kidney disease. We collected twenty-four hour urine specimens from 55 children by consecutive sampling. Urine specimens were tested for proteinuria by 20% sulfosalicylic acid test and spectrophotometry. Results Sensitivity and specificity of 20% sulfosalicylic acid test compared to spectrophotometry were 88.1% and 69.2%, respectively, with a positive predictive value and a negative predictive value of 90.2% and 64.3%, respectively. Conclusion The sulfosalicylic acid test had low sensitivity and specificity for detecting proteinuria, but it was more practical and less expensive compared to spectrophotometry. [Paediatr Indones. 2011;51:17-21].