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dc.contributor.authorSahil, M. Fauzie
dc.contributor.authorEdianto, Deri
dc.contributor.authorPasaribu, Hotma Partogi
dc.contributor.authorAdenin, Ichwanul
dc.contributor.authorMunthe, Indra G.
dc.contributor.authorDany A
dc.date.accessioned2014-12-12T01:21:28Z
dc.date.available2014-12-12T01:21:28Z
dc.date.issued2014-12-12
dc.identifier.otherFranz
dc.identifier.urihttp://repository.usu.ac.id/handle/123456789/42771
dc.descriptionMANUSKRIP DISTRIBUSI TIPE HUMAN PAPILLOMAVIRUS (HPV) PADAen_US
dc.description.abstractLATAR BELAKANG: Kanker serviks merupakan kanker yang tersering pada wanita di negara berkembang, dengan mortalitas yang masih tinggi. Sementara, cakupan program skrining di negara berkembang masih rendah. HPV merupakan faktor etiologi kanker serviks yang telah diteliti secara molekuler. Vaksin HPV merupakan pencegahan primer pada kanker serviks. Belum banyak penelitian tentang distribusi tipe HPV pada kanker serviks. Penelitian ini bertujuan untuk mengetahui distribusi tipe HPV, sehingga dapat digunakan untuk evaluasi efektivitas vaksin HPV yang telah ada. METODE: Pasien dengan diagnosis kanker serviks yang berobat ke RSUP H. Adam Malik Medan diikutsertakan secara consecutive. Dilakukan pengambilan sitologi apusan serviks untuk pemeriksaan genotyping HPV dengan metode polymerase chain reaction (PCR) pada 50 orang pasien. Sebanyak 30 sampel penelitian dapat dideteksi tipe HPV dan kemudian dilakukan pengolahan data dan analisis univariat untuk menentukan frekuensi. HASIL: Karakteristik subyek penelitian yang terbanyak adalah menikah pada usia > 20 tahun (56,7%), menikah satu kali (86,7%), paritas > 3 (56,7%) dan tidak mempunyai riwayat penggunaan kontrasepsi oral (83,3%). Tipe HPV 16 merupakan tipe HPV yang terbanyak (46,7%), diikuti tipe HPV 18 (33,3%). Tipe HPV 16 dominan ditemukan pada karsinoma sel skuamosa (56,5%) dan tipe HPV 18 dominan ditemukan pada adenokarsinoma (86,7%). KESIMPULAN: Tipe HPV 16 merupakan tipe yang paling sering ditemui dan ditemukan dominan pada jenis karsinoma sel skuamosa.en_US
dc.description.abstractBACKGROUND: Cervical cancer is the most common cancer among women in developing countries, with high mortality rate. Meanwhile, the scope of cervical screening program in developing countries is still very low. HPV is the etiological factor that has been established by molecular studies. HPV vaccine is the primary prevention of cervical cancer. There are few reliable studies exist about the distribution of HPV type in cervical cancer. The objective of the present study was to perceive the distribution of HPV type in cervical cancer, as of to be used to evaluate the effectiveness of available HPV vaccine. METHODS: Cervical cancer patients at H. Adam Malik General Hospital Medan were included consecutively. Fifty patients were assessed for cervical liquid based cytology and HPV genotyping by polymerase chain reaction (PCR) method. There were 30 samples of which HPV type can be detected. Data were analyzed by univariate analysis to determine the frequency. RESULTS: The common characteristics of study subjects were age of marriage > 20 years old (56,7%), had marriage for once (86,7%), parity > 3 (56,7%) and no history of the use of oral contraception (83,3%). HPV type 16 was the most common type (46,7%), followed by type 18 (33,3%). HPV type 16 was detected dominantly in squamous cell carcinoma (56,5%) and type 18 was detected dominantly in adenocarcinoma (86,7%). CONCLUSION: HPV type 16 was the most common type in this study and was detected dominantly in squamous cell carcinoma.en_US
dc.language.isoiden_US
dc.subjectHuman Papillomavirusen_US
dc.subjectHPVen_US
dc.subjectinvasive cervical canceren_US
dc.subjectHPV vaccineen_US
dc.titleDistribusi Tipe Human Papillomavirus (Hpv) Pada Kanker Serviks Invasif Di RSUP H. Adam Malik Medanen_US
dc.typeLecture Papersen_US


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