Gambaran Penggunaan Antihipertensi Pada PASIEN GAGAL GINJAL KRONIK DI Rumah Sakit Umum Pusat H. Adam Malik Medan: Permasalahan Terkait Obat

Abstract

Chronic kidney disease (CKD) is a pathophysiologic process with a diverse etiology that leads to reduced kidney function. Hypertension is one of the etiologic factors of kidney failure. In Indonesia, the prevalence of CKD in 2006 ranged 100-250/1 million people. This retrospective study aims to determine the patterns of use, regimen accuracy, and interactions of antihypertensive drugs provided to patients with CKD. A total of 63 medical records of patients with CKD who were given antihypertensive drugs were used as samples. The results showed that the most widely provided antihypertensive drugs was diuretics which reached 73%. The most frequently combined antihypertensive durgs were diuretic and ACE-I which reached 33%. Antihypertensive dosage regimens were in accordance with those that recommended for patients with CKD. However, because patients also suffered from other comorbidities, drug-drug interactions were also occured which in turn resulted in only 14% of the samples that reached the target blood pressure (130/80 mmHg). The most frequently drud interactions occured were between captopril and diltiazem.