Sintesis N‐Benzoyl Glutamida Melalui Amidasi Benzoyl Klorida Dengan Asam Glutamat

Abstract

N-benzoyl glutamide compound can be prepared by amidation benzoyl chloride with glutamic acid. Synthesis the amide used acetone/water solvent system at pH=12.0 through strring condition at 0-10 C. The N-benzoy glutamide product yielded from synthesis reaction was then isolated from reaction mixture user ethyl acetate solvent at pH 2-3 continued with purification step by solvent evaporation, crystallization in diethyl ether solvent to give solid crystal with mp. 135-136OC. Spectra of FT-IR and 1H-NMR have confirmed that the reaction product was in good agreement with the proposed structure. The compound was then assigned the surface tension which was then converted into HLB value using Du-Nuoy ring method and it give the value 5.274.