Effect of Iron Treatment on Nutritional Status of Children with Iron Deficiency Anemia
MetadataShow full item record
Background Iron has been shown to improve growth in children with iron deficiency anemia (IDA), as indicted by increases in height and weight. Frequently, malnutrition and iron deficiency coexist. Objective To determine the effect of iron treatment on nutritional status in children with IDA. Methods A randomized placebo-controlled clinical trial was conducted at Bilah Hulu, a subdistrict of Labuhan Batu, North Sumatera, Indonesia, between November 2006 and February 2007. Iron deficiency anemia was diagnosed if there anemia was present along with MCHC <31%, ROW index >220 and Mentzer index > 13. Elementary school children (8-12 years old) with IDA were randomly assigned to either receive a daily therapy of 6 mg iron/kg/day or a placebo for three months. Nutritional status was evaluated by anthropometric assessment before and after intervention. Results From 300 subjects recruited, there were 111 (37.2%) with iron deficiency anemia; 108 of them completed the therapy. After intervention, the iron and placebo groups had different mean hemoglobin concentrations (P <0.05), but there was no significant difference in mean weight and height gain between the two groups. Conclusion A significant increase in hemoglobin concentration was seen when iron was given, but did not affect weight and height increase in the subjects.