Perbandingan Efek Iritasi Kronik Pada Saluran Cerna Antara Aspirin Dalam Kapsul Alginat Dengan Tablet Ascardia®

Abstract

The comparison study of chronic irritation effects of aspirin to rabbit’s gastrointestinal track between aspirin formulated in alginate capsules and Ascardia® enteric coated aspirin tablet have been conducted. The chronic irritation test was done in 90 days to 18 rabbits, which were divided into 3 groups that consist of 6 rabbits for each group. First group was control group without giving drug. Second group was a group of rabbits which were given 80 mg of aspirin in alginate capsule, one capsule a day for 90 days. Third group was a group of rabbits which were given Ascardia® 80 mg tablet, one tablet a day for 90 days. After 90 days all the rabbits were killed and then the gastrointestinal track was observed macroscopically and microscopically by Hematoxylin Eosin coloring. The chronic irritation effect observed macroscopically showed that the gastrointestinal track (stomach, small intestine, and large intestine) of all rabbit which were given aspirin in alginate capsule didn’t show any irritation. However, 2 of 6 rabbits tested which were given Ascardia® tablet showed irritation on duodenum signed by wound and reddish. Stomach and large intestine of all rabbits which were given Ascardia® tablet were normal. The chronic irritation effect observed microscopically showed that the gastrointestinal track (stomach, small intestine, large intestine) of all rabbit which were given aspirin in alginate capsule didn’t show any irritation. However, 2 of 6 rabbits tested which were given Ascardia® tablet showed irritation on duodenum signed by erosion of epithelial cell and blood vascular dilatation . Stomach and large intestine of all rabbits which were given Ascardia® tablet were normal. It is concluded that aspirin given in alginate capsules is safer than that aspirin in Ascardia® tablet (enteric coated tablet).