Comparison of Oxygen Saturation Measured by Pulse Oximetry and Arterial Blood Gas Analysis in Neonates
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Background Arterial blood gas is usually beneficial to discern the nature of gas exchange disturbances, the effectiveness of compensation, and is required for adequate management. Although Pa02 is tim standard measurement of blood oxygenation, oxygen saturation measured by pulse oximetry (Sap02) is now a customary noninvasive assessment of blood oxygenation in newborn infants. Objective To compare oxygen saturation measured by pulse oximetry (Sap02) and arterial blood gas (Sa02), its correlation with other variables, and to predict arterial partial pressure of oxygen (Pa02) based on Sap02 values. Methods A cross sectional study was conducted on all neonates admitted to Pediatric Intensive Care Unit (PICU) during February 2001 to May 2002. Neonates were excluded if they had impaired peripheral perfusion and/or congenital heart defects. Paired t-test was used to compare Sap02 with Sa02. Correlation between two quantitative data was performed using Pearson's correlation. Regression analysis was used to predict Pa02 based on Sap02 values. Results Thirty neonates were included in this study. The difference between Sa02 and Sap02 was significant, There were significant positive correlations between heart rate Ipulse rate and TC02, HC03; respiratory rate and TC02, HC03, base excess (BE); core temperature and HC03, BE; surface temperature and pH, TC02, HC03, BE; SapOi and pH, Pa02; and significant negative correlation between Sap02 and PaC02; the correlations were weak. The linear regression equation to predict Pa02 based on Sap02 values was Pa02 = -79.828 + 1.912 Sap02 Conclusion Pulse oximetry could not be used in place of arterial blood gas analysis available for clinical purpose.