Effectivity Of Live Versus Heat Killed Probiotic In Children With Acute Diarrhoea
Objective: to determine the effectivity of live versus heat killed probiotic in children with acute diarrhea in diarrhea duration and frequency of diarrhoea. Methods: the study was conducted in June 2005-September 2006 in Sari Mutiara Hospital Medan. All charts of children in group age 4-24 months old with diagnosis acute diarrhoea enrolled and divided in to two groups. One group received live probiotic (LP) and other had heat killed probiotic (HKP). Both probiotic consumpt for seven days. The diarrhea duration and frequency diarrhea were noted. Formula milk was discontinued during diarrhea and all children received standard treatment of diarrhea and had probiotic as adjuvant treatment. Results: from the total of 150 children who came to visit pediatric outpatient clinic and pediatric ward, there were 108 children (70.6% boy and 29.4% girl) in group age 4-24 months with acute diarrhoea who meet the inclusion criteria were enrolled in this study. Amount of children who had live probiotic and heat killed probiotic were 54 each. In this study there were 26 (47%) and 25 (44%) in group aged 2-11 months and 28 (53%) and 29 (56%) in group aged 12-24 months in group Live probiotic and Heat killed probiotic, respectively. Boys more than girls. Some dehydration in 48 (82.4%) in group Live probiotic and 27(50%) in group heat killed probiotic. Mother of the almost graduated high school 28 (51.5%), employee 20 (35.3%) and unemployee in 34 (64.7%). All the father were employee, some of them work in informal sectors and 17.6% worked for government. There was significant difference in diarrhoeal duration in group live probiotic compared to heat killed probiotic (7.06 day vs 5.65 day; p=0.042), there was no significant differences in frequency diarrhea in both group live probiotic and heat killed probiotic (3.94 episodes vs 4.08 episodes, p=0.055). Conclusion: heat killed probiotic looked superior in shorten diarrhea duration compared to live bacteria in children with acute diarrhea, while there was no significant difference in frequency of diarrhea. It is required a longitudinal study with large sample to determine this findings.