Pemeriksaan Absorbsi Klorpromazin Hcl Dengan Pemberian Peroral Pada Kelinci
M. Timbul Simanjuntak
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The examination of Chlorpromazine Hydrochloride absorption has been conducted by in vivo on rabbit by calculating AUC value, Cmaks and tmaks. A similarity test has been conducted in the same method on Chlorpromazine Hydrochloride tablet. Determination of Chlorpromazine Hydrochloride was conducted with Spectrophotometric visible at 710 nm by reacting Chlorpromazine Hydrochloride with reagents of potassium ferricyanide solution, ferric chloride solution and 1:1 acetic acid solution with aquabidest as the solvent. The result was tested by ANAVA (Analysis of Variance) statistical analysis method. The result indicated that Chlorpromazine Hydrochloride tablet compared with Chlorpromazine Hydrochloride have the different AUC and tmaks values, but Cmaks is not different, and tablet form reached tmaks that longer than Chlorpromazine Hydrochloride did.